The levels of cartonectin and procalcitonin in patients with chronic periodontitis and hypertension

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Ata O. S., ÇANAKÇI C. F., ÖZKAN KARASU Y.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.48, ss.410-416, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1515/tjb-2022-0237
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals
  • Sayfa Sayıları: ss.410-416
  • Anahtar Kelimeler: cartonectin, chronic periodontitis, essential hypertension, inflammation, procalcitonin, C-REACTIVE PROTEIN, SALIVARY PROCALCITONIN, INFLAMMATORY RESPONSE, SERUM PROCALCITONIN, BIOMARKERS, ASSOCIATION, DISEASE, POPULATION, ADIPOKINE, SEPSIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objectives: This study aimed to examine the effects of chronic periodontitis and essential hypertension on serum and salivary cartonectin (CTRP3) and procalcitonin (ProCT) levels.Methods: 60 non-smokers were seperated into four groups as; 15 people with essential hypertension (EH) and chronic periodontitis (CP) (HT+ CP+), 15 with EH (HT+ CP-), 15 with CP (HT- CP+), 15 control (HT- CP-). PPD, CAL, PI and GI were measured. All groups had their serum and saliva samples collected. Serum and saliva procalcitonin (ProCT) were measured using an electroluminescence method, and cartonectin (CTRP3) levels were determined by enzyme-linked immunosorbent assay.Results: When compared to the control group, serum and saliva cartonectin (CTRP3) levels were considerably lower in all groups (respectively p<0.0001, p<0.0001). The serum cartonectin (CTRP3) levels were substantially higher in the HT- CP+ group than in the HT+ CP- group (p=0.002). Serum procalcitonin (ProCT) concentrations were found to be lowest in the HT- CP- group and highest in the HT+ CP+ group. Serum ProCT concentrations did not vary significantly across groups (p=0.110). Salivary procalcitonin (ProCT) levels were below the detection limit in all groups.Conclusions: When periodontitis coexist with hypertension in individuals, they may have adversely affect each other due to the same sathways in the pathogenesis of these two disorders. So we can suggest that, serum and saliva cartonectin (CTRP3) may play a role during hypertension and periodontal inflammation and represent a novel future therapeutic target.