Akademik Veri Yönetim Sistemi
8th International Conference on Advances in Natural and Applied Sciences (ICANAS 2025), Antalya, Türkiye, 28 - 31 Ekim 2025, ss.128, (Özet Bildiri)
Azorubine is a well-known food colorant. Despite having a widespread use, it may have several toxic properties [1]. Although toxicity tests determine hazardous potential, the complexity of targets that can be changed, such as enzymes and sensitive proteins that can be inhibited by molecules, and the interactions that occur between a large number of molecules during experimental applications are limitations of toxicity tests [2]. On the other hand, in silico computational methods have become a procedure that has recently increased as powerful application tools that reduce target limitations. This method, defined as target fishing, aims to predict possible biological targets by taking into account the chemical structures of molecules. In this study, different online applications (SwissTargetPrediction, SEA, Pharmmapper, LigAdvisor and Targetnet) were used to determine proteins that may interact with Azorubine using the target fishing method. In order to present the expected interactions of the 22 target proteins determined, the Molecular Docking process was performed with the Schrödinger program. With this process, ligand models were performed and the biological activities of these proteins in accordance with the literature were defined. An infrastructure was created for planning subsequent experimental studies by specifying the functions of the proteins and associated diseases.