The protective role of selenium against the genotoxicity induced by aflatoxin B-1 in root cells of crop plants

Agar G., ALPSOY L., YILDIRIM N.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.14, sa.10, ss.849-853, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 10
  • Basım Tarihi: 2005
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.849-853
  • Anahtar Kelimeler: aflatoxin B-1, selenium, genotoxicity, Zea mays, Vicia faba, DIETARY SELENIUM, CHROMOSOME ABERRATIONS, COVALENT BINDING, ADDUCT FORMATION, VITAMIN-E, LIVER, RATS, METABOLITE, CALCIUM, DAMAGE
  • Atatürk Üniversitesi Adresli: Evet

Özet

The protective role of selenium against the genotoxicity induced by aflatoxin B-1 (AFB(1)) was studied in root cells of crop plants. Experimental evidences showed that chromosomal aberrations can be induced by all treated AFB(1) doses (0.1, 0.2 and 0.4 ppm). On the other hand, the frequencies of chromosomal aberration can be effectively decreased by treatment with sodium selenite (Na2SeO3, 0.08, 8 and 800 ppm) together with AFB(1). These results suggest that selenium could effectively inhibit AFB(1) induced chromosomal aberration which may be partially responsible for its mutagenic effect. Besides, the protective role of selenium against aflatoxin B, induced chromosomal aberrations is correlated with its concentrations.