Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma

CACCIATORE I., Fornasari E., MARINELLI L., EUSEPI P., CIULLA M., Ozdemir O., ...Daha Fazla

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.109, ss.402-411, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ejps.2017.08.030
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.402-411
  • Anahtar Kelimeler: Histone deacetylase, Glioblastoma, Memantine, Mutual prodrug, HISTONE DEACETYLASE INHIBITORS, GROWTH-FACTOR RECEPTOR, RANDOMIZED PHASE-III, C6 GLIOMA-CELLS, FACTOR-KAPPA-B, CONSTITUTIVE ACTIVATION, MALIGNANT GLIOMAS, TUMOR-SUPPRESSOR, TEMOZOLOMIDE, MULTIFORME
  • Atatürk Üniversitesi Adresli: Evet

Özet

Glioblastoma is one of the most aggressive malignant primary brain cancer in adults. To date, surgery, radiotherapy and current pharmacological treatments are not sufficient to manage this pathology that has a high mortality rate (median survival 12-15 months).