Changes in bone turnover markers in adolescents with gastroesophageal reflux disease treated with lansoprazole

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Islek A., Erol Kizilelma N., Keskin H., Ozturk N.

ACTA GASTRO-ENTEROLOGICA BELGICA, cilt.85, sa.4, ss.565-571, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.51821/85.4.10906
  • Dergi Adı: ACTA GASTRO-ENTEROLOGICA BELGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Sayfa Sayıları: ss.565-571
  • Anahtar Kelimeler: Bone turnover, collagen type-1 cross linked C-telopeptide, collagen type-1 crosslinked N-telopeptide, deoxypyridinoline, osteocalcin, proton pump inhibitor, PROTON-PUMP INHIBITORS, POSTMENOPAUSAL WOMEN, MINERAL DENSITY, HIP FRACTURE, CALCIUM, THERAPY, RISK, RECOMMENDATIONS, METABOLISM, OMEPRAZOLE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Proton pump inhibitors (PPIs) have been suggested to lead to bone resorption, while the effects of PPIs on the bone mineral metabolism in children has received only limited attention in literature to date. The present study investigates whether lansoprazole alters bone turnover markers in adolescents with gastroesophageal reflux disease (GERD). Patients and methods: Included in the study were adolescents aged 16-18 with GERD and a healthy volunteers group. The GERD patient group was treated with lansoprazole 30 mg once daily for eight weeks. The serum calcium, phosphorus, magnesium, alkaline phosphatase (ALP), parathormone (PTH), 25 (OH) vitamin D, osteocalcin and urinary calcium, creatinine, deoxypyridinoline (DPD), collagen type-1 crosslinked C-telopeptide (CTX) and collagen type-1 crosslinked N-telopeptide (NTX) of both groups were studied before and after the end of the treatment. Results: A comparison of the 30 patients with GERD and the 30 volunteers revealed no significant difference in the serum calcium, phosphorus, magnesium, ALP, urinary calcium/creatinine ratio, 25 (OH) vitamin D and PTH levels measured before and after the lansoprazole treatment, while the osteocalcin, DPD, CTX and NTX values were found to be higher after treatment when compared to those at pre- treatment. Conclusions: The results of this study reveal that eight weeks of treatment with 30 mg lansoprazole daily increased the bone turnover markers of CTX, NTX, DPD and osteocalcin in adolescents aged 16-18. (Acta gastroenterol. belg., 2022, 85, 565-571).