Akademik Veri Yönetim Sistemi
THE EUROPEAN RESEARCH JOURNAL, cilt.9, ss.517-528, 2023 (Hakemli Dergi)
Objectives: Laryngeal squamous cell carcinomas (LSCC) is one of the most common aggressive neoplasms
of the head and neck region. There is a significant need for identification of successful and accurate prognostic
markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the
differential expressions of inhibitor growth (ING) family members and to evaluate the prognostic values of
deregulated ING genes in LSCC.
Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs at
mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the
protein level using Western Blot analysis.
Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancers including
LSCC. ING3 expression was significantly upregulated in LSCC tissue samples at both mRNA and protein
level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and
neck cancer.
Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant
upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.