Oxidative Stress in Rat Cortex

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Ceylan H., Koçpınar E. F., Gönül Baltacı N., Erdoğan O., Budak H.

III. International Congress of the Molecular Biology Association, İzmir, Türkiye, 10 - 12 Ekim 2014, ss.1

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.1
  • Atatürk Üniversitesi Adresli: Evet

Özet

Iron is an indispensible element for brain development, oxygen transport, neurotransmitter

synhtesis as well as normal brain functions [1]. However, excess iron intake increases free

radical formation. These reactive oxygen metabolites may be deleterious for nervous system,

and it induces neurotoxicity. Biological systems have an endogenous defense mechanism to

protect cells against oxidative damage via the antioxidant defense system [2]. The main

purpose of this study was to examine the toxic effects of iron on the brain antioxidant system

at the enzymatic and molecular level. Our results showed that brain antioxidant systems was

affected by iron overload at the enzymatic and molecular level, but the actual effect of iron

was observed at protein level. Reduced glutathione (GSH) level, either increased or decreased

GSH level is an indicator of oxidative stress [3], was markedly reduced in the present of iron.

Keywords: Iron, Rat, Cortex, Neurotoxicity, Glutathione System!