Synthesis and spectral investigation of some methyl-substituted 3-(2-pyridyl)-2-(2-thienyl)thiazolidin-4-one derivatives

Fidan I., KAZAZ C., ŞAHİN E., KABAN Ş.

JOURNAL OF CHEMICAL RESEARCH, sa.5, ss.296-300, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3184/030823410x12746350585058
  • Dergi Adı: JOURNAL OF CHEMICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.296-300
  • Atatürk Üniversitesi Adresli: Evet

Özet

Some heteroaryl-substituted thiazolidin-4-one derivatives have been synthesised starting from thiophenecarbox-aldehydes, 2-amino-6-methylpyridine and 2-mercaptoacetic acid. However, the use of 2-mercaptopropanoic acid gave the thiazolidinone derivatives as a mixture of cis-and trans-isomers. The configuration of both the cis-and trans-isomers has been established by NOE-difference experiments. Furthermore, the stereochemistry of one of the trans isomers was established by X-ray crystallography.