Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-,4,7-ethanoisoindole-1,3(2H)-dione derivatives

Ozbek O., Usta N. C., Gurdere M. B., Aslan O. N., Budak Y., Ceylan M.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.192, sa.10, ss.1153-1157, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 192 Sayı: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/10426507.2017.1354209
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1153-1157
  • Anahtar Kelimeler: Thiazole, 4,7-ethanoisoindole-1,3(2H)-dione, antibacterial activity, 2-AMINOTHIAZOLE DERIVATIVES, ANTIMICROBIAL ACTIVITIES, PHTHALIMIDE DERIVATIVES, BIOLOGICAL EVALUATION, THIAZOLE DERIVATIVES, ANTITUMOR-ACTIVITY, AGENTS, ANALOGS, DESIGN, SERIES
  • Atatürk Üniversitesi Adresli: Hayır

Özet

A series of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives were synthesized and evaluated for their antimicrobial activity. The structures of the synthesized derivatives (9a-j) were confirmed by means of IR, H-1-NMR, C-13-NMR and elemental analyses. All the compounds 9a-j showed activity against all microorganisms. Compounds 9a, 9c-d, and 9j exhibit potent antibacterial activity against tested S. pyogenes. Compounds 9c showed higher activity than standards against C. perfringes. 9a-e, 9j and 9i possess good activity against A. tumefacen.