The Effects of Necrostatin-1 on Cerebral Vasospasm- Induced Subarachnoid Hemorrhage

ŞAHİN M. H., AKYÜZ M. E., KADIOĞLU H. H.

TURKISH NEUROSURGERY, cilt.32, sa.6, ss.923-929, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5137/1019-5149.jtn.35167-21.4
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.923-929
  • Anahtar Kelimeler: Necrostatin-1, Stereology, Subarachnoid hemorrhage, Vasospasm, Rat, EARLY BRAIN-INJURY, INFLAMMATION, NECROPTOSIS, APOPTOSIS, CYTOKINES, NECROSIS, CELLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

AIM: To investigate the effects of necrostatin-1 (NEC-1) on subarachnoid hemorrhage (SAH)-induced vasospasm in a rat model.MATERIAL and METHODS: A total of 59 male Wistar albino rats were randomly divided into six groups: control (group 1), sham (group 2), decapitation one hour after SAH (group 3), decapitation 48 hours after SAH (group 4), NEC-1 given 15 minutes before SAH and decapitation one hour after SAH (group 5), and NEC-1 given 24 hours after SAH and decapitation 48 hours after SAH (group 6). NEC-1 (1 uq) was administered intracisternally in dimethyl sulfoxide (DMSO) (2.6 uq). After decapitation, the cross-sectional areas and wall thicknesses of basilar arteries were determined histopathologically using stereological methods.RESULTS: NEC-1 administered before SAH had a statistically significant preventive effect on vasospasm following SAH. Arterial wall thicknesses were found to be significantly increased in the SAH without NEC-1 groups but not in the control group, the sham group or the NEC-1 groups.CONCLUSION: The results of this study show that NEC-1 can prevent vasospasm in rats and has cytoprotective effects. Further studies are needed for the clinical use of this agent.