Akademik Veri Yönetim Sistemi
Türk Doğa ve Fen Dergisi, cilt.12, sa.1, ss.163-170, 2023 (Hakemli Dergi)
Pseudoexfoliation syndrome (PEX) is a systemic disease that occurs as a result of aggregation of extracellular matrix material in ocular tissues and visceral organs. The etiopathogenesis of the PEX is not fully known. The purpose of our study is to examine the enzyme activities in some metabolic pathways that may be associated with etiopathogenesis. Carbonic anhydrase (CA), glutathione reductase (GR), aldose reductase (AR), paraoxonase (PON) enzymes activity in aqueous and serum samples, also serum selenium levels were investigated. According to the results, CA hydratase enzyme activity levels were higher in the serum samples with PEX compared to the control samples (p < 0.05). Aqueous CA hydratase and aqueous/serum PON, GR and AR activity levels did not differ significantly among the study samples (p > 0.05). Based on the relationship of carbonic anhydrase with aqueous production and glaucoma, increased serum CA hydratase activity may help to understand the PEX etiopathogenesis and mechanism of conversion to glaucoma.