Akademik Veri Yönetim Sistemi
Türkiye Çocuk Hastalıkları Dergisi, 2023 (Hakemli Dergi)
Objective: In this study, it was aimed to evaluate the preoperative and postoperative oxidative stress levels of children
with obstructive adenotonsillar hypertrophy and to compare the obtained data with healthy children.
Material and Methods: 25 patients and 25 healthy controls were included in the prospective study conducted between
March and September 2015. In the study sample, children who were diagnosed with adenotonsillar hypertrophy due
to chronic tonsillitis, snoring and mouth breathing and who were planned for adenotonsillectomy were included in
the patient group. Control group included 25 healthy volunteers with the same demographic characteristics. Serum
and urine samples were collected from the patient group twice, before and after surgery, and once from the control
group. 8-hydroxy-2-deoxyguanosine levels of all samples were determined by EIA method, protein carbonyl levels were
determined by ELISA method and malondialdehyde levels were determined by manual spectrophotometric method.
Results: In the study, it was found that the serum malondialdehyde levels of children with adenotonsillar hypertrophy
were significantly higher than the control group (p=0.003) and that there was no difference in terms of other parameters
(p>0.05). After the operation, it was determined that the levels of all three parameters evaluated significantly decreased
compared to before (p<0.05). It was determined that there was a statistically significant and weak correlation between
malondialdehyde and 8-hydroxy-2-deoxyguanosine values before the operation (p=0.003, r=0.566).
Conclusion: Hypertrophic adenotonsillar, which is common in the pediatric population, causes many clinical conditions
and adversely affects the health and quality of life of children. In line with our findings, we can say that serum and urine MDA
levels and tissue PCO levels are useful markers in the evaluation of oxidative damage in children with obstructive ATH and
may help to elucidate the etiopathogenesis of the disease. Considering the effects of ATH on health, it is recommended
to be considered as an important health problem and to examine the clinical, biochemical and histopathological studies
of the disease in a larger sample group.