Therapeutic effect of Tarantula cubensis extract on indomethacin induced gastric ulcers in rats

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Makav M., Gelen V., Gedikli S., Atila Uslu G., Uslu H., Eroğlu H. A.

THAI JOURNAL OF VETERINARY MEDICINE, cilt.50, sa.4, ss.559-566, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 4
  • Basım Tarihi: 2020
  • Dergi Adı: THAI JOURNAL OF VETERINARY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.559-566
  • Anahtar Kelimeler: indomethacin-induced gastric ulcer, NF-kB, 8-OHdG, Rat, Tarantula Cubensis extract, NONSTEROIDAL ANTIINFLAMMATORY DRUG, HEME OXYGENASE-1
  • Atatürk Üniversitesi Adresli: Evet

Özet

Non-steroid anti-inflammatory drugs (NSAIDs) have widely been used in patients but side-effects associated with NSAID are also common. Tarantula cubensis extract (TCE) is an antiphlogistic, demarcative, homeopathic and necrotizing drug with wound healing effects in farm animals. However, the therapeutic effects of TCE on gastric ulcers has not been investigated. The aim of this study was to investigate the gastroprotective effects of TCE against indomethacin-induced gastric injury in rats.