Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents.

Marinelli, L; Fornasari, E; Di, Stefano; Turkez, Hasan; Genovese, S; Epifano, F; Di, Biase; Costantini, E; D'Angelo, C; Reale, M; Cacciatore, I

doi:10.1016/j.bmcl.2018.11.057

Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents.

Marinelli L., Fornasari E., Di S., Turkez H., Genovese S., Epifano F., ...Daha Fazla

Bioorganic & medicinal chemistry letters, cilt.29, ss.194-198, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.bmcl.2018.11.057
Dergi Adı: Bioorganic & medicinal chemistry letters
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.194-198
Anahtar Kelimeler: Alzheimer's disease, Gly-L-Pro-L-Glu, Neuroinflammation, Pseudopeptides, N-TERMINAL TRIPEPTIDE, GROWTH-FACTOR-I, GLYCINE-PROLINE-GLUTAMATE, ALZHEIMERS-DISEASE, DIMETHYL ESTER, PEPTIDE, NEUROINFLAMMATION, DIFFERENTIATION, INTERLEUKIN-18, INFLAMMATION
Atatürk Üniversitesi Adresli: Hayır

Özet

This study investigated the anti-inflammatory effects of novel pseudotripeptides (GPE 1-3) as potential candidates to counteract neuroinflammation processes in Alzheimer's disease.