Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Atatürk Üniversitesi, Fen Fakültesi, Kimya, Türkiye
Tezin Onay Tarihi: 2020
Tezin Dili: Türkçe
Öğrenci: Gökçen Akınalp
Danışman: Derya Anıl
Özet:
SYNTHESIS OF SOME BIOLOGICAL ACTIVE ISOXAZOL-CHALCONE HYBRID COMPOUNDS
Gökçen AKINALP
Supervisor: Assoc. Prof. Dr. Derya AKTAŞ ANIL
Purpose: Within the scope of this thesis, the synthesis and determination of
the anticancer properties of eleven new 3,5-diaryl isoxazol derivatives that could be potential anticancer agents were targeted.
The designed derivatives are intended to be potential drug candidate molecules
in cancer treatment.
Method: For this purpose, chalcone derivatives were obtained by
Claisen-Schmidt condensation reaction of related acetophenones and benzaldehydes.
Eleven new 3,5-diaryl-isoxazole compounds were obtained from the addition
reaction of chalcones with TsNHOH. The structures of all synthesized compounds
were determined by IR, 1H-NMR,
13C-NMR and elemental analysis.
Findings: Within the scope of the study, eleven 3,5-diaryl isoxazole derivatives
were synthesized in high purity with 10-68% yield. Biological potentials of the
compounds obtained against prostate cancer were determined with cancer PC3 and
non- tumorigenic PNT1a cells. The compound 26 with the highest anticancer
activity were determined to be the prototype of this series.
Results: Findings of positive synergistic effects of new hybrid compounds formed
by using chalcone and isoxazole pharmacophores on cancer cells have revealed.
Significant results of the newly obtained hybrid compounds in pancreatic cancer
cell line were observed.
Keywords: Chalcone, Isoxazole, Claisen-Schmidt Condensation Reaction