Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles

Liu S., Zhang J., Fu R., Feng H., Chu Y., Huang D., ...Daha Fazla

Food Chemistry, cilt.373, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 373
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.foodchem.2021.131498
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Oleanolic acid, 0-carotene, Self-assembly, Hepatoprotective, Nanocarrier, BETA-CAROTENE NANOEMULSIONS, PHYSICOCHEMICAL STABILITY, CHEMICAL-STABILITY, IONIC-STRENGTH, DELIVERY, TECHNOLOGIES, ENHANCEMENT, CASEIN, PH
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2021 Elsevier LtdPoor water solubility and stability of β-carotene (Car) greatly hinder its application in foods. Herein, naturally occurring bioactive oleanolic acid (OA) was used as a nanocarrier to overcome these shortcomings by fabricating Car-loaded OA nanoparticles (Car/OA NPs). Through optimization, the encapsulation efficiency and loading capacity reached 80.7% and 32.6%, respectively. Systematic characterization suggested that Car was successfully encapsulated, and hydrogen bonding and hydrophobic interactions are the main forces facilitating the self-assembly and encapsulation. Compared with free Car, Car/OA NPs exhibited significantly improved water dispersibility and enhanced stability against UV radiation, heat, ionic strength, and acidic conditions. Further, Car/OA NPs provided gastric protection, delayed-release in simulated gastric fluid (SGF) and controlled release in simulated intestinal fluid (SIF). Additionally, both OA NPs and Car/OA NPs showed markedly inherent hepatoprotective effects. This work demonstrates that OA NPs can be used as inherent bioactive nanocarriers to deliver hydrophobic nutrients and bioactive food components.