Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles
Food Chemistry, cilt.373, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 373
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.foodchem.2021.131498
- Dergi Adı: Food Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
- Anahtar Kelimeler: Oleanolic acid, 0-carotene, Self-assembly, Hepatoprotective, Nanocarrier
- Atatürk Üniversitesi Adresli: Evet
Özet
© 2021 Elsevier LtdPoor water solubility and stability of β-carotene (Car) greatly hinder its application in foods. Herein, naturally occurring bioactive oleanolic acid (OA) was used as a nanocarrier to overcome these shortcomings by fabricating Car-loaded OA nanoparticles (Car/OA NPs). Through optimization, the encapsulation efficiency and loading capacity reached 80.7% and 32.6%, respectively. Systematic characterization suggested that Car was successfully encapsulated, and hydrogen bonding and hydrophobic interactions are the main forces facilitating the self-assembly and encapsulation. Compared with free Car, Car/OA NPs exhibited significantly improved water dispersibility and enhanced stability against UV radiation, heat, ionic strength, and acidic conditions. Further, Car/OA NPs provided gastric protection, delayed-release in simulated gastric fluid (SGF) and controlled release in simulated intestinal fluid (SIF). Additionally, both OA NPs and Car/OA NPs showed markedly inherent hepatoprotective effects. This work demonstrates that OA NPs can be used as inherent bioactive nanocarriers to deliver hydrophobic nutrients and bioactive food components.