Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Liu S., Yang Q., Zhang J., Yang M., Wang Y., Sun T., ...Daha Fazla

Food Chemistry, cilt.372, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 372
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.foodchem.2021.131343
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Stilbene-glycoside, Carboxymethyl chitosan, Chitosan hydrochloride, Stability, Complex coacervation, ANTIOXIDANT ACTIVITY, ANTHOCYANINS, MECHANISM, ALGINATE, ENCAPSULATION, FABRICATION, IMPACT, PH
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2021 Elsevier LtdStilbene-glycoside (THSG) is a promising dietary supplement with remarkable biological properties, however, its poor stability and low oral bioavailability hinder its application as an ingredient in functional foods. Herein, stilbene-glycoside-loaded nanoparticles (THSG-NPs) coated with carboxymethyl chitosan (CMC) and chitosan hydrochloride (CHC) using a complex coacervation method were successfully prepared for enhancing the stability of THSG. The optimized preparation parameters were 2.5 mg/mL CMC, 1.0 mg/mL CHC, 1.5 mg/mL THSG and preparation temperature of 25 °C, under which the experimentally designed particles averaged 381.9 nm with encapsulation efficiency (EE) of 68.6%. Solid-state characterization was assessed by Fourier transform infrared spectroscope and Differential scanning calorimetry. THSG-NPs showed significant protective effects against heat and solar radiation and exhibited remarkable pH-dependent and controlled release. This work demonstrated that enhanced stability and delayed release of THSG could be achieved using THSG-NPs, which could contribute to its potential application in the functional foods industry.