A quick and effective methodology for analyzing dinotefuran and its highly polar metabolites in plum using liquid chromatography-tandem mass spectrometry

RAHMAN M. M., Abd El-Aty A. M., Kabir M. H., CHUNG H. S., LEE H. S., HACIMÜFTÜOĞLU F., ...Daha Fazla

Food Chemistry, cilt.239, ss.1235-1243, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 239
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.foodchem.2017.07.073
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1235-1243
  • Anahtar Kelimeler: Dinotefuran, Polar metabolites, Matrix effect, Plum, QuEChERS, ETHYL-ACETATE EXTRACTION, SOLID-PHASE EXTRACTION, PESTICIDE-RESIDUES, MULTIRESIDUE METHOD, NEONICOTINOID INSECTICIDES, SAMPLE PREPARATION, UNCERTAINTY ANALYSIS, BABY FOOD, GAS, TEA
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2017 Elsevier LtdA simple and effective method was developed for analyzing dinotefuran and its three metabolites (MNG, UF, and DN) in plum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Due to the polarity and high water miscibility, dinotefuran and some of its metabolites (especially DN) have some limitations to be extracted with acetonitrile and salt following the “QuEChERS” sample preparation methodology. Alternatively, the samples were extracted with methanol, and purified with dispersive-solid phase extraction procedure (d-SPE) using primary secondary amine (PSA) and C18 sorbents after filtration, and mass up. Due to the suppression effect originated from plum matrix, matrix-matched calibration curves, which provided good linearity with coefficient of determination (R2) ≥ 0.998, were used for quantification of all analytes. Blank plum samples fortified with 2 spiking levels (10 × LOQ and 50 × LOQ) yielded satisfactory recoveries for all tested analytes in the range of 83.01 to 110.18% with relative standard deviation (RSD) ≤ 8.91. The method was successfully applied to field-incurred plum samples and dinotefuran and all metabolites were positively detected and quantified. In conclusion, we suggest that the method can be expanded to polar compounds having solvent and partitioning problems in any of the versions of QuEChERS.