Edible pentacyclic triterpenes: A review of their sources, bioactivities, bioavailability, self-assembly behavior, and emerging applications as functional delivery vehicles.

Liu S., Liu H., Zhang L., Ma C., HASSIBELNABY A. M. A.

Critical reviews in food science and nutrition, cilt.64, sa.16, ss.5203-5219, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 16
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/10408398.2022.2153238
  • Dergi Adı: Critical reviews in food science and nutrition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, CINAHL, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, SportDiscus, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.5203-5219
  • Anahtar Kelimeler: pentacyclic triterpene, structure, bioactivity, bioavailability, nanostructural assembly, delivery carrier, PERFORMANCE LIQUID-CHROMATOGRAPHY, ORAL BIOAVAILABILITY, BETULINIC ACID, ARJUNOLIC ACID, GLYCYRRHIZIC ACID, OLEANOLIC ACID, ASIATIC ACID, IN-VITRO, PHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2022 Taylor & Francis Group, LLC.Edible pentacyclic triterpenes (PTs) are a group of nutraceutical ingredients commonly distributed in human diets. Existing evidence has proven that they have various biological functions, including anticancer, antioxidant, anti-inflammatory and hypoglycemic activities, making them as “functional factor” for a long time. However, their properties of strong hydrophobicity, poor permeability, poor absorption, and rapid metabolism result in low oral bioavailability, which dramatically hinders their efficacy for use. Recently, free PTs have successively been found to self-assemble or co-assemble into self-contained nanostructures with enhanced water dispersibility and oral bioavailability, which seems to be an efficient processing method for increased oral efficacy. Of particular interest, formulating them into nanostructures can also be introduced as functional delivery carriers for bioactive compounds or drugs with various advantages, such as improved stability, controlled release, enhanced oral bioavailability, synergistic bioactivity, and targeted delivery. This review systematically summarized the chemical structures, plant sources, bioactivities, absorption, metabolism, and oral bioavailability of PTs. Notably, we emphasized their self-assembly properties and emerging role as functional delivery carriers for nutrients, suggesting that PT nanostructures are not only efficient oral forms when introduced into foods but also functional delivery materials for nutrients to expand their commercial food applications.